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Showing posts with label 23andMe. Show all posts
Showing posts with label 23andMe. Show all posts

Thursday, January 12, 2012

23andMe Reconsiders Several Planned Actions


 Thanks to those who complained about 23andMe's plans to drop non-paying subscribers from their data base, 23andMe announced they have reconsidered their plans. When the kits were first sold there were no subscription fees, then about a year ago, the company began requiring a one year $9. a month commitment to get new info, but said after that time, customers could keep their access to medical information and genealogy matches, just get go new info if they dropped the subscription. Many were very upset by the December announcement that they would just simply be dropped. This move would have also deprived subscription paying customers of many of their matches, distant cousins with the potential to break down brick walls.

Company statement:
 http://spittoon.23andme.com/2012/01/08/an-update-to-23andme-customers/


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Tuesday, January 10, 2012

Generational Surnames and Autosomal DNA Matching

 

Generational Surnames and Autosomal DNA Matching

By Roberta Estes

My interest in this topic is due to the number of adoptees I work with. DNA testing for genetic genealogy often represents the best, if not the only hope to adoptees of finding their genetic families.

I'm working with a woman who has two possible surnames to work with. Both are possibilities and the answer could be that neither of these surname is the right one. However, I've managed to put together some genealogy on both lines and I wanted to know how often people are finding matches in the genealogy data bases at Family Tree DNA and at 23andMe for their surnames represented by their parents, their grandparents, and their great-grandparents. For this exercise, I don't care how many matches to each surname they have, only IF they have any match to that surname.

For example, if your parents surnames are Smith and Jones, for example, and you have any matches that include the surnames Smith or Jones in their surnames listed as their ancestors, the answer is yes. If both Smith and Jones have matches, then you have 2 for 2 in the first generation. 
 
The second generation, grandparents, includes 4 surnames, the 2 represented by your parents plus two more, your mother's mother's surname (Anderson) and your father's mother's surname (Ferverda), for a total of 4. If Smith and Jones are already represented, then we need to determine if Anderson and Ferverda have matches. Let's say neither do, so for this generation, you have 2 of 4 possible. 
 
For the great-grandparents generation, we add 4 more ancestors, for a total of 8. Let's say that those surnames are Moore, Brown, Quincy and Scott and let's say that only Scott shows up in the list of surnames of your matches. So for this generation you have 3 of 8, your two parents, plus Scott.

The real question here is what is the likelihood that someone who is adopted will find their biological surnames in the surnames listed by their matches.

An ad hoc survey on both the ISOGG and the DNA-Genealogy lists in January 2012 received results for a total of 57 people who had been tested. A couple of people provided only partial information for a variety of reasons, so the totals in each group are slightly different.
Of the group who replied, for the first generation, their parents, the following was found:
  • 20 people had no matches to their parents surnames
  • 21 people had one match to their parents surnames
  • 14 people had matches to both of their parents surnames
What this means to adoptees is there is a 38% likelihood that none or one of your parents surnames are represented in your matches. There is a 25% likelihood that both of your parents surnames are listed. Overall, there is a 64% likelihood that you will find at least one of your parents surnames listed in your matches. Of course, the question remains, which surnames are which.

Moving to the second, grandparents, generation we find the following.
  • 16 people had zero matches to any of their 4 grandparents surnames
  • 14 people had 1 match to their 4 grandparents surnames
  • 11 people had 2 matches to their 4 grandparents surnames
  • 7 people had 3 matches to their 4 grandparents surnames
  • 6 people had matches to all 4 of their grandparents surnames
This means that there is a 30% chance that none of your parents or grandparents surnames are found among your matches. However, there is also a 70% chance that at least one of your grandparents surnames will be found among your matches. There is only a small chance, 7%, that all 4 of your grandparents surnames will be found among your matches.
Moving to the third generation, great-grandparents, we find the following:

  • 11 people had zero matches to any of their 8 great-grandparents surnames
  • 9 people had 1 match to their 8 great-grandparents surnames
  • 6 people had 2 matches to their 8 great-grandparents surnames
  • 12 people had 3 matches to their 8 great-grandparents surnames
  • 7 people had 4 matches to their 8 great-grandparents surnames
  • 4 people had 5 matches to their 8 great-grandparents surnames
  • 2 people had 6 matches to their 8 great-grandparents surnames
  • 4 people had 7 matches to their 8 great-grandparents surnames
  • 1 person had matches to all 8 of their great-grandparents surnames

There is a 20% likelihood that none of your parents, grandparents or great-grandparents surnames will be found among your matches. However, there is also an 80% likelihood that at least one of those 8 surnames will be found among your matches. 
 
The results of the 3 generation, 8 surname survey, when plotted, take the shape of the traditional bell shaped curve, with a lump that would likely smooth out with more samples. Twenty one percent of the people will find 3 of their 8 grandparents surnames among their matches.
Most people told me where they tested, or I could easily discern the information due to the test name. Many of them also included their total number of matches. The total of matches at 23andMe was, as a rule, was between 4 and 5 times the number of matches at Family Tree DNA. However, the commentary was pretty uniformly that people were disappointed with the contacts, or lack thereof, at 23andMe, in general, and when contact was made, that many had either no interest in or little information on their genealogy, rendering the contact useless or nearly so. One person wondered why someone would test at Family Tree DNA if they weren't interested in genealogy, so the response problem is not unique to 23andMe clients.

Of the people who responded to the survey, 13 of them had tested at both 23andMe and Family Tree DNA. Those results are included separately. Of these at the 8 surname level, there were a total of 21 matches at Family Tree DNA and 34 matches at 23andMe, so testers are obtaining more surname matches at 23andMe, but only about one third more, not in proportion to the 400% to 500% more matches than at Family Tree DNA. This is likely a direct reflection of the number of people at 23andMe that are interested in the health information and not in the genealogical aspect. However, one would think that if they went to the trouble to enter their surnames, they would have some interest in family history.

Interesting aspects were that maybe half of the people had some complicating factor, such as a highly endogamous population or a patronymic population, both of which clearly affect the potential of finding matching surnames. Equally as interesting was the one man who had no matches for any of his 8 grandparents surnames but had relatively "vanilla" colonial American surnames. 
 
As both data bases increase in size, I would expect the numbers and percentages of matches to rise as well. The message here is that today, in January of 2012, for adoptees, there is about a 38% chance that one of your parents surnames is found among your matches, a 64% chance that one or both of your parents surnames will be found, a 70% chance that one or more of your grandparents surnames will be found and 80% chance that one or more of your great-grandparents surnames will be found.






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Tuesday, January 3, 2012

23andMe Beseiged with Complaints

When 23andMe started selling the kits that included genealogy matching results, there was no subscription fee.  You paid once and that was it.  About 18 months ago, they started selling an "upgrade" and along with that upgrade came a monthly fee to continue receiving updates.  At that time, they stated that if you stopped paying the fee after a year's commitment, you would not receive any new health updates nor matches, but the ones you had at the time you stopped paying would remain. 
 
Dick Eastman covers this here:


Now, they have reversed their position and before Christmas announced that they will no longer honor their committment.  If you allow your monthly subscription to lapse, which has increased from $5 per month to $9 per month, you will no longer have access to your results at all.  The genetic genealogy community has banded together to voice our displeasure with their intended failure to honor their initial commitment by creating a petition that we are signing.
The petition can be found at:


I encourage everyone to sign this petition.  I have.

I am also voting with my money and I no longer encourage people to test at 23andMe.  Family Tree DNA provides this same test for genealogists, without the health info obviously, and there is no subscription fee on top of the initial test price of $99.  $9 per month is $108 per year and it has risen from $60 per year, a price jump of $56% in one fell swoop. 
 
I feel that 23andMe is not being a good corporate citizen by changing their policies and then trying to pretend they were always that way. 
 
Roberta Estes



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Monday, August 2, 2010

Follow Newsweek Reporter as She Tries Out the Autosomal DNA Tests

You can even keep up with Mary Carmichael on Twitter if you want to.

DNA Dilemma: The FAQs

Some guidelines and details for my week-long project.

I’m trying to choose whether or not I want to take a direct-to-consumer genetic scan of hundreds of thousands of variants in my genome. Before we get started with the big questions, here are some basic queries that many consumers may have, as well as some information about myself and this project.

So how will this work, anyway?

I'm currently in possession of a direct-to-consumer genetic test—I just haven't decided if I'll use it. For three days this week, I'll pose a question a day to a variety of sources about the value of these tests. I'll post their answers on this site, along with my reaction. I'll also be soliciting opinions from commenters and people following me on Twitter. On Friday, Aug. 6, I'll evaluate everything I've learned and reveal whether I've decided to take the test.

Which DTC genetic testing kit did you buy?
Quantcast
Currently, there are two large, reputable companies offering scans of hundreds of thousands of genetic markers directly to consumers, the same ones that introduced the tests to the public, launching within a day of each other in 2007: 23andMe and deCODE. I don’t plan to reveal here which company’s kit I bought, because I don’t want to become a de facto ad for either company if I take the test. However, it’s worth noting that there are some differences between the firms. 23andMe charges a lot less, for instance—$499 for a health and ancestry scan, compared to the $2,000 price of the deCODEme complete scan—and tests for about half as many genetic variants, 550,000 compared to deCODE’s 1 million. Aside from the occasional embarrassing slip-up, 23andMe does a fine job of quality control in identifying genes. So does deCODE, which isn’t a testing company so much as a lab that happens to sell tests while producing a near-unrivalled body of genetics research. Both companies have also put a lot of effort into conveying their findings in innovative (if not always fully transparent) ways. They try to interpret their data with a lengthy report and continuous updates on the Web; deCODE’s service even links to the original research that underlies the test.

Continued here:

http://www.newsweek.com/2010/08/02/dna-dilemma-the-faqs.html

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Tuesday, March 9, 2010

23andMe Half Price Sale





23andMe is being offered at half price for the rest of this month.

https://www.23andme.com/partner/foa/

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Sunday, February 14, 2010

Stephen Colbert Learns He is the Whitest Person Ever DNA Tested

Henry Louis Gates Jr. goes on the Stephen Colbert show to inform him he is the whitest person ever DNA tested. Great satire!!! Humorous look at DNA testing. Stephen was among several celebrities tested as part of the Faces of America genealogy series. The first episode appeared February 10th. The second episode will air Wed. night February 17th at 7 CST 8 EST. But be sure and check your local listings.


Henry Louis Gates, Jr.
The Colbert ReportMon - Thurs 11:30pm / 10:30c
www.colbertnation.com
Colbert Report Full EpisodesPolitical HumorSkate Expectations


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Saturday, February 13, 2010

Comparing Apples to Oranges

by Janet Crain
After almost a decade of Y Chromosome and mtDNA testing dominating the layman user consumer market, autosomal tests have come within a price range that many Americans, despite the lousy economy, can afford. Here a reporter orders and uses tests from three different companies; Navigenics, 23andMe, and deCODEme to see which is the best. Guess who won out.

Web DNA Tests Raise Self-Absorption to a New Level

In which the writer compares the sometimes scary, sometimes entertaining services of Navigenics, 23andMe and deCODEme

I have fascinating genes. At least, they're fascinating to me. For the last several weeks I've been getting up close and personal with my DNA as I compared three major direct-to-consumer genetic testing services. These companies, which claim to identify their customers' genetic predispositions for various diseases, are products of the multibillion-dollar, multiyear effort to map the human genome. It's a place where biotech meets infotech.

To test the services, I signed up for all three; Navigenics, 23andMe, and deCODEme at the same time. Once I registered and paid online, each service sent me a kit to collect my genetic material and a mailer to return it. Navigenics and 23andMe use saliva samples for analysis. DeCODEme has a more involved process, using what looks like a specialized tongue depressor to take a scraping of the inside of your cheek. I was a bit worried about messing things up, but a video on the Web site showed me how to do it properly. To measure response times, I made sure to send back the kits simultaneously.

Read it all here:

http://www.businessweek.com/magazine/content/10_05/b4165079447289.htm

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Monday, September 21, 2009

New 23andMe Autosomal Test Opportunity

New 23andMe Autosomal Test Opportunity – Very Limited Time

Recently I have been invited to gather a group to participate in a very special beta group at 23andMe.

I want to state very clearly this offer is for a very limited time. If you wish to participate, KITS MUST BE ORDERED BY SEPTEMBER 30TH (2009) AND RETURNED TO THE LAB NO LATER THAN OCTOBER 30TH.

Secondly, I had to agree to not post the price online nor the special discount code for our group online, but let’s just say that the price is in the ballpark of the DNA tests we are used to from the major DNA testing companies. If you want to know more, e-mail me privately and I’ll send you both the price and the discount code to order, but I must ask you to not post the price info nor the code online anyplace. You can distribute this to family and friends under the same conditions.

When I took this test, it cost $995. The current public price is $399 for the full service test and this special beta price is dramatically less, in fact, it’s only slightly more than their Research Edition test listed here
https://www.23andme.com/researchrevolution/compare/, but because of the special nature of this project, you get the full test for the discounted price which is slightly more than the Research Edition.

For this special price, you receive all of their Ancestry results which you can see here
https://www.23andme.com/ancestry/ and their 116 genetic traits which you can see here https://www.23andme.com/health/. As new tests come online, your results are provided for those tests for free, or at least this has been the policy to date. I’ve been quite pleased as new information has been added to my personal account.

For those who don’t know, 23andMe is a DNA testing company that provides some information to genealogists regarding haplogroup information and percentages of ethnicity, but has traditionally focused more on genetic health traits.
www.23andme.com

New Autosomal Focus and Product – Relative Finder

In the past few months, their focus has changed somewhat.

First, they are now only one of two companies who provide a percentage of ethnicity and it’s included in their one-price test. This percentage includes European, African and Asian, and for the purposes of the people in the US looking for Native American ancestry, the Asian percentage is proxy for the Native American. It’s not perfect, but it’s the best there is today.

Second, they have been working very hard on autosomal testing, which is indeed the focus of these beta groups of 50 individuals. A new product called “Relative Finder” will compare your DNA to that of other individuals to see who you match and who you don’t and will hopefully help you to discover people to whom you are related. The demonstration for this new feature is not yet available, but will be soon. It may not be available before the end of the discount period, so if you are interested in participating, do NOT wait on this demo to be available or you may miss the window of opportunity (Sept. 30th).

Many of us have taken the Codis, autosomal or DNAPrint tests with the hopes of determining what ethnic group we match or if we are a match with a particular individual. These tests use between 15 and 21 markers, typically the same markers used for forensics. This new test uses over half a million markers for each person.

Rather than try to describe this to you, I’m going to quote Ann Turner (MD) who was one of two authors who wrote the book “Trace Your Roots with DNA: Using Genetic Tests to Explore Your Family Tree” which is still the best basics book on genetic genealogy available.

Dr. Turner says, “The current discount is for the full product, and it only applies during a beta test period for a new feature at 23andMe. The type of test offered by 23andMe doesn't replace Y-STR and mtDNA HVR (or FGS), although "deep ancestry" results can help sort out some coincidental matches.

The potential breakthrough for genetic genealogy is the vast amount of autosomal data: 550,000 SNPs, vs the couple of handfuls of CODIS-style STRs you probably ordered elsewhere. If this pans out, it means that projects
(surname/geographical/ethnic) don't need to confine themselves to the straight paternal or maternal lines, but they can include people whose ancestry zigzags back and forth between males and females.

Genetic genealogists just aren't dialed in to thinking about all the "other" ancestral lines. In order to introduce and (hopefully!) demonstrate the utility of autosomal testing for finding connections between people, discounts were offered to a few project administrators.

For instance, one way to use autosomal testing in a surname project would be to calibrate whether a Y-STR match represents recent ancestry (say 4th cousins or so) or is likely to be more distant. Also, women who don't have a straight paternal line could participate in a surname-oriented project if they think they might share a recent ancestor with a male in the project.

Projects limited to a well-defined geographic area or ethnicity may be able to identify multiple connections between people and assemble an autosomal picture of the founders. Again, this would open up projects to people who lack a straight maternal or paternal line.

Nothing like this has ever been attempted before, so we are just beginning to explore the potential. It will also be important to understand the limitations.

One way to use this type of testing would be to narrow down the inheritance of medical conditions. Some of you may be investigating a medical condition that is found in your extended family, like I've been doing for an autosomal dominant hereditary hearing impairment where the gene is unknown. By testing 6 cousins, some with and some without the condition, I've been able to narrow down the possibilities to one region on chromosome 15. Some of you may even know the name of the gene but wonder if you've inherited the same stretch of DNA as a cousin with the condition.

Some of you may have found some clues about an adopted great-grandfather and wondered if you've really located a living cousin. The Family Inheritance diagram at 23andMe would highlight an area of DNA that you share. (Anyone can create a demo account and view various diagrams and reports for a real family, the "Mendels".)”

A third way would be to test multiple people from a family, ethnic group such as the Amish or a particular geography (such as the Cumberland Gap) who are or might be related in some manner and to see which chromosomes they share.

Basicly “relatedness” testing can also be achieved in this manner for people who think they may be related and for whom the siblingship or extended family testing has proven inconclusive.

Well, you get the picture. There are many other hypotheses that could be investigated with autosomal DNA once you begin to think about it.

Here, Blaine Bettinger discusses his experiences with the 23andMe test:
http://www.thegeneticgenealogist.com/2009/03/11/genetic-testing-with-23andme/

Here he discusses the ancestry portion of his testing and the Ethnic percentages:
http://www.thegeneticgenealogist.com/2009/03/12/genetic-testing-with-23andme-ancestry-testing/

A related article can be found here:
http://www.thegeneticgenealogist.com/2009/09/21/the-future-of-genetic-genealogy-tracing-dna-to-individual-ancestors/

The Bottom Line

The bottom line is this. I can’t tell you what you’ll get out of this endeavor except for their normal products, which alone is an incredible value for the price you will pay. You will be participating in a new research endeavor and you may indeed be part of finding that “Holy Grail” for genealogists, discovering how to effectively use autosomal DNA to determine not only race and ethnicity, but degrees of relatedness to other individuals. One thing is for sure, if you don’t participate, you’ll never know. I’ll be there. Hope to see you there too.

If you are interested, e-mail me personally and I will send you the pricing information and the code to join.

Roberta Estes
robertajestes@att.net

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